Billy (Mark Duplass) and Ray (Sterling K. Brown) are lifelong best friends and the last two men on earth. Living in a custom biosphere designed by Ray – a brilliant scientist – they enjoy the basic necessities and creature comforts that make it possible to retain a sense of what life used to be. When their carefully managed ecosystem begins to inexplicably fail, Billy and Ray face an ominous future unless life finds a way… Directed by Mel Eslyn and co-written by Eslyn and Duplass, BIOSPHERE is an unpredictable comedy exploring mortality and masculinity.